Pethidine (Meperidine); A Therapeutic Friend or Foe???? Pethidine (Meperidine) was synthetically derived in 1938 as an anticholinergic agent (substances which block the action of the neurotransmitter Acetylcholine in the Peripheral and Central nervous system), but was discovered to possess analgesic properties shortly after. Although it’s a weak agonist at the opioid receptor (mu receptor), anecdotal evidence suggests it […]